Genetic Characterization of Multidrug-Resistant, Extended-Spectrum- β-Lactamase-Producing Vibrio cholerae O1 Outbreak Strains, Mpumalanga, South Africa, 2008 | Zendy

Husna Ismail | Zendy; Anthony M. Smith | Zendy; Arvinda Sooka | Zendy; Karen H. Keddy | Zendy

Open Access

Genetic Characterization of Multidrug-Resistant, Extended-Spectrum- β-Lactamase-Producing Vibrio cholerae O1 Outbreak Strains, Mpumalanga, South Africa, 2008

Author(s) -

Husna Ismail,

Anthony M. Smith,

Arvinda Sooka,

Karen H. Keddy

Publication year - 2011

Publication title -

journal of clinical microbiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.349

H-Index - 255

eISSN - 1070-633X

pISSN - 0095-1137

DOI - 10.1128/jcm.00293-11

Subject(s) - vibrio cholerae , cholera , microbiology and biotechnology , serotype , outbreak , quinolone , biology , el tor , multiple drug resistance , vibrionaceae , virology , antibiotic resistance , antibiotics , bacteria , genetics

Thirty-one antimicrobial-resistant, extended-spectrum-β-lactamase-producing strains of Vibrio cholerae O1 serotype Ogawa associated with an outbreak of cholera in South Africa (2008) were investigated. Ten selected cholera strains were PCR positive for the SXT element, harbored mutations in the quinolone resistance-determining regions of GyrA (Ser83-Ile) and ParC (Ser85-Leu), and produced TEM-63 β-lactamase.

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