Identification of Mycobacterial Antigens in Human Urine by Use of Immunoglobulin G Isolated from Sera of Patients with Active Pulmonary Tuberculosis | Zendy

Sun Hee Kim | Zendy; NanEe Lee | Zendy; Jong Seok Lee | Zendy; Jeong Hwan Shin | Zendy; Ju Yeon Lee | Zendy; JeongHeon Ko | Zendy; Chulhun L. Chang | Zendy; Yong-Sam Kim | Zendy

Open Access

Identification of Mycobacterial Antigens in Human Urine by Use of Immunoglobulin G Isolated from Sera of Patients with Active Pulmonary Tuberculosis

Author(s) -

Sun Hee Kim,

NanEe Lee,

Jong Seok Lee,

Jeong Hwan Shin,

Ju Yeon Lee,

JeongHeon Ko,

Chulhun L. Chang,

Yong-Sam Kim

Publication year - 2016

Publication title -

journal of clinical microbiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.349

H-Index - 255

eISSN - 1070-633X

pISSN - 0095-1137

DOI - 10.1128/jcm.00236-16

Subject(s) - tuberculosis , antigen , immunology , medicine , urine , mycobacterium tuberculosis , antibody , point of care testing , urinary system , tuberculosis diagnosis , immunoglobulin g , virology , pathology

Point-of-care (POC) diagnostic testing of tuberculosis (TB) is a tremendous unmet need. In this study, four urinary mycobacterial antigens were identified through two independent approaches using IgG capture and immunodepletion methods. Among these, ModC was validated by a multiple reaction monitoring (MRM) method. As expected, the biomarkers elevated the clinical validity of TB diagnosis when combined with preexisting markers.

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