Severe Soft Tissue Infection Caused by a Non-Beta-Hemolytic Streptococcus pyogenes Strain Harboring a Premature Stop Mutation in the sagC Gene | Zendy

Jonathan Jantsch | Zendy; Roman G. Gerlach | Zendy; Armin Ensser | Zendy; Samira Dahesh | Zendy; Isabel Popp | Zendy; C. Heeg | Zendy; Oliver Bleiziffer | Zendy; Thomas Merz | Zendy; Theresia Schulz | Zendy; Raymund E. Horch | Zendy; Christian Bogdan | Zendy; Victor Nizet | Zendy; Mark van der Linden | Zendy

Open Access

Severe Soft Tissue Infection Caused by a Non-Beta-Hemolytic Streptococcus pyogenes Strain Harboring a Premature Stop Mutation in the sagC Gene

Author(s) -

Jonathan Jantsch,

Roman G. Gerlach,

Armin Ensser,

Samira Dahesh,

Isabel Popp,

C. Heeg,

Oliver Bleiziffer,

Thomas Merz,

Theresia Schulz,

Raymund E. Horch,

Christian Bogdan,

Victor Nizet,

Mark van der Linden

Publication year - 2013

Publication title -

journal of clinical microbiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.349

H-Index - 255

eISSN - 1070-633X

pISSN - 0095-1137

DOI - 10.1128/jcm.00175-13

Subject(s) - streptococcus pyogenes , microbiology and biotechnology , mutation , strain (injury) , biology , gene , streptococcaceae , virology , genetics , bacteria , antibiotics , staphylococcus aureus , anatomy

We recovered a non-beta-hemolytic Streptococcus pyogenes strain from a severe soft tissue infection. In this isolate, we detected a premature stop codon within the sagC gene of the streptolysin S (SLS) biosynthetic operon. Reintroduction of full-length sagC gene on a plasmid vector restored the beta-hemolytic phenotype to our clinical isolate, indicating that the point mutation in sagC accounted for loss of hemolytic activity. To the best of our knowledge, this is the first report to demonstrate that a severe soft tissue infection can be caused by a non-beta-hemolytic S. pyogenes strain lacking a functional SagC.

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