Integrating the Xpert MTB/RIF Assay into a Diagnostic Workflow for Rapid Detection of Mycobacterium tuberculosis in a Low-Prevalence Area | Zendy

Vanessa Deggim | Zendy; Ákos Somoskövi | Zendy; Antje Voit | Zendy; Erik C. Böttger | Zendy; Guido V. Bloemberg | Zendy

Open Access

Integrating the Xpert MTB/RIF Assay into a Diagnostic Workflow for Rapid Detection of Mycobacterium tuberculosis in a Low-Prevalence Area

Author(s) -

Vanessa Deggim,

Ákos Somoskövi,

Antje Voit,

Erik C. Böttger,

Guido V. Bloemberg

Publication year - 2013

Publication title -

journal of clinical microbiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.349

H-Index - 255

eISSN - 1070-633X

pISSN - 0095-1137

DOI - 10.1128/jcm.00151-13

Subject(s) - mycobacterium tuberculosis , medicine , tuberculosis , genexpert mtb/rif , microbiology and biotechnology , tuberculosis diagnosis , mycobacterium , virology , biology , pathology

The Xpert MTB/RIF assay is a rapid and fully automated real-time PCR assay. The performance of the Xpert MTB/RIF assay as a primary screening test for urgent clinical specimens was evaluated during a 2-year period. The results showed that replacing smear microscopy with the Xpert MTB/RIF assay facilitates laboratory handling and improves the sensitivity and specificity of Mycobacterium tuberculosis detection.

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