Open AccessDirect Comparison of the GenoType MTBC and Genomic Deletion Assays in Terms of Ability To Distinguish between Members of the Mycobacterium tuberculosis Complex in Clinical Isolates and in Clinical Specimens
Author(s) -
Ákos Somoskövi,
Jillian Dormandy,
Jeremy Rivenburg,
Maria Pedrosa,
Melinda McBride,
Max Salfinger
Publication year - 2008
Publication title -
journal of clinical microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.349
H-Index - 255
eISSN - 1070-633X
pISSN - 0095-1137
DOI - 10.1128/jcm.00105-07
Subject(s) - mycobacterium tuberculosis complex , tuberculosis , genotype , mycobacterium tuberculosis , biology , mycobacterium , microbiology and biotechnology , virology , medicine , genetics , pathology , gene
The automated GenoType MTBC assay was evaluated for the ability to detect and identify members of the Mycobacterium tuberculosis complex. In addition to 35 reference strains and 157 clinical isolates, performance of this assay was tested directly on 79 smear-positive clinical specimens. The assay proved as accurate as the reference deletion analysis for all 192 isolates and detected and identified M. tuberculosis complex members in 93.2% of the specimens containing the M. tuberculosis complex.
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