Open AccessParvovirus among Patients with Cytopenia of Unknown Origin in Brazil: a Case-Control Study
Author(s) -
Sheila de Oliveira Garcia,
Walter Kleine Neto,
Antônio Charlys da Costa,
Sabri Saeed Sanabani,
Alfredo Mendrone,
Juliana Pereira,
Éster Cerdeira Sabino
Publication year - 2011
Publication title -
journal of clinical microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.349
H-Index - 255
eISSN - 1070-633X
pISSN - 0095-1137
DOI - 10.1128/jcm.00077-11
Subject(s) - genotype , cytopenia , etiology , parvovirus , medicine , case control study , gastroenterology , biology , immunology , bone marrow , genetics , virus , gene
The molecular prevalence of human parvovirus B19V (B19V) in bone marrow (BM) samples from 120 cases with cytopenias of unknown etiology was compared with that in samples from 45 BM donors (control group 1) and 120 oncohematological patients (control group 2) to determine the role that B19V genotypes may play in unexplained cytopenias. Of the 285 participants, the BM samples of 39 (13.7%) contained B19V DNA (21 with genotype 1, 5 with genotype 2, and 13 with genotype 3). The prevalences of B19V were similar between case and control subjects (15.0% versus 12.7%, respectively). Genotypes 2 and 3 were associated with older age and were detected in similar proportions between case and control group 2 subjects. The results of this study do not support a role for B19V genotype variants in the etiology of unexplained cytopenias.