Open AccessIdentification of Nudix Hydrolase Family Members with an Antimutator Role in Mycobacterium tuberculosis and Mycobacterium smegmatis
Author(s) -
Tiago Dos Vultos,
Jesús Blázquez,
Jean Rauzier,
Ivan Matić,
Brigitte Gicquel
Publication year - 2006
Publication title -
journal of bacteriology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.652
H-Index - 246
eISSN - 1067-8832
pISSN - 0021-9193
DOI - 10.1128/jb.188.8.3159-3161.2006
Subject(s) - mycobacterium smegmatis , biology , mycobacterium tuberculosis , mycobacterium , tuberculosis , microbiology and biotechnology , virology , bacteria , genetics , medicine , pathology
Mycobacterium tuberculosis andMycobacterium smegmatis MutT1, MutT2, MutT3, and Rv3908 (MutT4) enzymes were screened for an antimutator role. Results indicate that both MutT1, inM. tuberculosis andM. smegmatis , and MutT4, inM. smegmatis , have that role. Furthermore, an 8-oxo-guanosine triphosphatase function for MutT1 and MutT2 is suggested.