Open AccessIron-Responsive Regulation of Biofilm Formation in Staphylococcus aureus Involves Fur-Dependent and Fur-Independent Mechanisms
Author(s) -
Miranda Johnson,
Alan Cockayne,
Peter H. Williams,
Julie A. Morrissey
Publication year - 2005
Publication title -
journal of bacteriology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.652
H-Index - 246
eISSN - 1067-8832
pISSN - 0021-9193
DOI - 10.1128/jb.187.23.8211-8215.2005
Subject(s) - biofilm , staphylococcus aureus , biology , microbiology and biotechnology , polysaccharide , staphylococcus , mechanism (biology) , bacteria , biochemistry , genetics , philosophy , epistemology
We have shown that Staphylococcus aureus biofilm production is induced in iron-restricted conditions and is repressed by iron via a Fur-independent mechanism, while Fur has both positive and negative regulatory roles in low iron. Furthermore, there is no significant increase in polymeric N-acetylglucosamine polysaccharide expression to account for induction of biofilms in low iron.