Open AccessGlobal Regulation of Gene Expression by ArlRS, a Two-Component Signal Transduction Regulatory System of Staphylococcus aureus
Author(s) -
Xudong Liang,
Zheng Li,
Christina Landwehr,
Dwayne Lunsford,
David Holmes,
Yinduo Ji
Publication year - 2005
Publication title -
journal of bacteriology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.652
H-Index - 246
eISSN - 1067-8832
pISSN - 0021-9193
DOI - 10.1128/jb.187.15.5486-5492.2005
Subject(s) - biology , repressor , signal transduction , gene , response regulator , staphylococcus aureus , regulation of gene expression , virulence , gene expression , microbiology and biotechnology , regulator , autolysis (biology) , two component regulatory system , regulator gene , microarray , transduction (biophysics) , extracellular , genetics , mutant , bacteria , biochemistry , enzyme
Staphylococcus aureus expresses various cell wall-associated and extracellular virulence factors, coordinately controlled by different two-component signal transduction systems and transcriptional regulators. In this study, we used microarray technology to identify the genes regulated by ArlR. The microarray data indicate that ArlR functions as a positive regulator and also as a negative repressor to directly and/or indirectly mediate the expression of at least 114 genes involved in different functions, including autolysis, cell division, growth, and pathogenesis.