Open AccessPhoP Can Activate Its Target Genes in a PhoQ-Independent Manner
Author(s) -
Sergio Lejona,
María Eugenia Castelli,
María Laura Cabeza,
Linda J. Kenney,
Eleonora García Véscovi,
Fernando C. Soncini
Publication year - 2004
Publication title -
journal of bacteriology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.652
H-Index - 246
eISSN - 1067-8832
pISSN - 0021-9193
DOI - 10.1128/jb.186.8.2476-2480.2004
Subject(s) - phosphorylation , biology , gene , extracellular , salmonella enterica , function (biology) , two component regulatory system , microbiology and biotechnology , mutant , biochemistry , escherichia coli
The PhoP/PhoQ two-component system controls the extracellular magnesium depletion response in Salmonella enterica. Previous studies have shown that PhoP is unable to up-regulate its target genes in the absence of PhoQ function. In this work, we demonstrate that PhoP overexpression can substitute for PhoQ- and phosphorylation-dependent activation. Either a high concentration of PhoP or activation via phosphorylation stimulates PhoP self-association.