Open AccessThe F-ATPase Operon Promoter of Streptococcus mutans Is Transcriptionally Regulated in Response to External pH
Author(s) -
Wendi L. Kuhnert,
Guolu Zheng,
Roberta C. Faustoferri,
Robert G. Quivey
Publication year - 2004
Publication title -
journal of bacteriology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.652
H-Index - 246
eISSN - 1067-8832
pISSN - 0021-9193
DOI - 10.1128/jb.186.24.8524-8528.2004
Subject(s) - operon , biology , chloramphenicol acetyltransferase , streptococcus mutans , atpase , stringent response , acetyltransferase , chloramphenicol , enzyme , microbiology and biotechnology , biochemistry , gene expression , gene , promoter , bacteria , escherichia coli , genetics , acetylation , antibiotics
Streptococcus mutans F-ATPase, the major component of the acid-adaptive response of the organism, is transcriptionally upregulated at low pH. Fusions of the F-ATPase promoter to chloramphenicol acetyltransferase indicated that pH-dependent expression is still observed with a short promoter that contains a domain conserved between streptococcal ATPase operons.