Open AccessThe Phosphotransferase System of Streptomyces coelicolor Is Biased for N -Acetylglucosamine Metabolism
Author(s) -
Harald Nothaft,
Dagmar Dresel,
Andreas Willimek,
Kerstin Mahr,
Michael Niederweis,
Fritz Titgemeyer
Publication year - 2003
Publication title -
journal of bacteriology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.652
H-Index - 246
eISSN - 1067-8832
pISSN - 0021-9193
DOI - 10.1128/jb.185.23.7019-7023.2003
Subject(s) - streptomyces coelicolor , pep group translocation , phosphotransferase , biology , phosphotransferases , biochemistry , phosphoenolpyruvate carboxykinase , locus (genetics) , streptomyces griseus , genetics , streptomyces , gene , microbiology and biotechnology , kinase , mutant , bacteria
Mutation of the crr-ptsI gene locus revealed that Streptomyces coelicolor uses the phosphotransferase system (PTS) for N-acetylglucosamine uptake. crr, ptsI, and ptsH, which encode the three general PTS phosphotransferases, are induced by N-acetylglucosamine but not by other PTS substrates. Thus, the S. coelicolor PTS is biased for N-acetylglucosamine utilization, a novel feature that distinguishes this PTS from others.