Open AccessCarboxy-Terminal Region Involved in Activity of Escherichia coli TolC
Author(s) -
Hidetoshi Yamanaka,
Hiroshi Izawa,
Keinosuke Okamoto
Publication year - 2001
Publication title -
journal of bacteriology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.652
H-Index - 246
eISSN - 1067-8832
pISSN - 0021-9193
DOI - 10.1128/jb.183.23.6961-6964.2001
Subject(s) - escherichia coli , biology , bacterial outer membrane , escherichia coli proteins , membrane transport protein , transport protein , biochemistry , enterobacteriaceae , residue (chemistry) , peptide sequence , membrane , membrane protein , gene
The Escherichia coli TolC acts as a channel tunnel in the transport of various molecules across the outer membrane. Partial-deletion studies of tolC revealed that the region extending from the 50th to the 60th amino acid residue from the carboxy terminus plays an important role in this transport activity of TolC.