Open AccessIsocitrate dehydrogenase kinase/phosphatase: identification of mutations which selectively inhibit phosphatase activity
Author(s) -
Timothy P. Ikeda,
Elizabeth K. Houtz,
David C. LaPorte
Publication year - 1992
Publication title -
journal of bacteriology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.652
H-Index - 246
eISSN - 1067-8832
pISSN - 0021-9193
DOI - 10.1128/jb.174.4.1414-1416.1992
Subject(s) - isocitrate dehydrogenase , biology , phosphatase , biochemistry , protein phosphatase 2 , acid phosphatase , dusp6 , microbiology and biotechnology , enzyme , kinase , gene , residue (chemistry)
Mutations in aceK, the gene encoding isocitrate dehydrogenase kinase/phosphatase, which selectively inhibit phosphatase activity have been isolated. These mutations yield amino acid substitutions within a 113-residue region of this 578-residue protein. These mutations may define a regulatory domain of this protein.