Open AccessThe Escherichia coli K-12 cyn operon is positively regulated by a member of the lysR family
Author(s) -
Young-Chul Sung,
James A. Fuchs
Publication year - 1992
Publication title -
journal of bacteriology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.652
H-Index - 246
eISSN - 1067-8832
pISSN - 0021-9193
DOI - 10.1128/jb.174.11.3645-3650.1992
Subject(s) - operon , biology , gene , genetics , l arabinose operon , escherichia coli , peptide sequence , gal operon , regulator gene , nucleic acid sequence , trp operon , protein family , regulation of gene expression
A regulatory gene, cynR, was found to be located next to the cyn operon but transcribed in the opposite direction. cynR encodes a positive regulatory protein that controls the cyn operon as well as its own synthesis. Positive regulation of the cyn operon requires cyanate and the cynR protein, but the negative autoregulation of the cynR gene appears to be independent of cyanate. The predicted amino acid sequence of the cynR protein derived from the DNA sequence was found to have significant homology to the predicted amino acid sequence of the lysR family of regulatory proteins.