Open AccessEscherichia coli strains with multiple DNA repair defects are hyperinduced for the SOS response
Author(s) -
Patricia L. Foster
Publication year - 1990
Publication title -
journal of bacteriology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.652
H-Index - 246
eISSN - 1067-8832
pISSN - 0021-9193
DOI - 10.1128/jb.172.8.4719-4720.1990
Subject(s) - biology , sos response , ap site , escherichia coli , uracil dna glycosylase , dna repair , dna glycosylase , nucleotide excision repair , dna (apurinic or apyrimidinic site) lyase , mutation , dna damage , dna , mutagenesis , genetics , microbiology and biotechnology , gene
Escherichia coli strains defective for the repair of apurinic/apyrimidinic sites and for the UvrABC excision repair pathway could be constructed if they also carried a mutation in ung, which encodes uracil glycosylase, or sulA, which encodes an SOS-inducible inhibitor of septation. The resultant strains were sensitive to alkylation damage and hyperinduced for the SOS response, but had unpredictable spontaneous mutation rates.