Open AccessLoss of 4.5S RNA induces the heat shock response and lambda prophage in Escherichia coli
Author(s) -
David B. Bourgaize,
Teresa A. Phillips,
Ruth A. VanBogelen,
Paula G. Jones,
Frederick C. Neidhardt,
Maurille J. Fournier
Publication year - 1990
Publication title -
journal of bacteriology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.652
H-Index - 246
eISSN - 1067-8832
pISSN - 0021-9193
DOI - 10.1128/jb.172.2.1151-1154.1990
Subject(s) - prophage , escherichia coli , biology , heat shock , rna , lysis , ribosome , heat shock protein , shock (circulatory) , microbiology and biotechnology , hsp70 , lysogenic cycle , genetics , bacteriophage , gene , medicine
During depletion of 4.5S RNA, cells of Escherichia coli displayed a heat shock response that was simultaneous with the first detectable effect on ribosome function and before major effects on cell growth. Either 4.5S RNA is involved directly in regulating the heat shock response, or this particular impairment of protein synthesis uniquely induces the heat shock response. Several hours later, lambda prophage was induced and the cells lysed.