Open AccessRegulation of the Escherichia coli glyA gene by the metR gene product and homocysteine
Author(s) -
Michael Plamann,
George V. Stauffer
Publication year - 1989
Publication title -
journal of bacteriology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.652
H-Index - 246
eISSN - 1067-8832
pISSN - 0021-9193
DOI - 10.1128/jb.171.9.4958-4962.1989
Subject(s) - biology , escherichia coli , gene product , gene , methionine , homocysteine , regulation of gene expression , genetics , gene expression , biochemistry , amino acid
The methionine component of glyA gene regulation in Escherichia coli K-12 was investigated. The results indicate that the glyA gene is positively controlled by the metR gene product. Activation of glyA by the MetR protein requires homocysteine, an intermediate in methionine biosynthesis. The positive-acting metR regulatory system functions independently of a regulatory system shown previously to control glyA gene expression.