Open AccessO-antigen variation in Salmonella spp.: rfb gene clusters of three strains
Author(s) -
Naresh K. Verma,
Neil B. Quigley,
Peter R. Reeves
Publication year - 1988
Publication title -
journal of bacteriology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.652
H-Index - 246
eISSN - 1067-8832
pISSN - 0021-9193
DOI - 10.1128/jb.170.1.103-107.1988
Subject(s) - biology , operon , salmonella typhi , salmonella , microbiology and biotechnology , gene , antigen , serotype , genetics , virology , bacteria , escherichia coli
The O antigens of Salmonella serogroups A, B, and D differ structurally in their side-chain sugar residue. These genes encoding O-antigen biosynthesis are clustered in the rfb operon. We report here the molecular cloning and analysis of the rfb operons of Salmonella paratyphi A (serogroup A) and S. typhi (serogroup D). The regions of DNA nonhomology between the rfb operons of these serogroup A, B, and D representatives are identified, and the evolutionary derivation of serogroup A from a serogroup D progenitor is discussed.