The Yersinia pestis Rcs Phosphorelay Inhibits Biofilm Formation by Repressing Transcription of the Diguanylate Cyclase Gene hmsT | Zendy

Yicheng Sun | Zendy; Xiao-Peng Guo | Zendy; B. Joseph Hinnebusch | Zendy; Creg Darby | Zendy

Open Access

The Yersinia pestis Rcs Phosphorelay Inhibits Biofilm Formation by Repressing Transcription of the Diguanylate Cyclase Gene hmsT

Author(s) -

Yicheng Sun,

Xiao-Peng Guo,

B. Joseph Hinnebusch,

Creg Darby

Publication year - 2012

Publication title -

journal of bacteriology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.652

H-Index - 246

eISSN - 1067-8832

pISSN - 0021-9193

DOI - 10.1128/jb.06243-11

Subject(s) - yersinia pestis , biofilm , biology , transcription (linguistics) , signal transduction , microbiology and biotechnology , second messenger system , cyclase , gene , bacteria , biochemistry , genetics , enzyme , virulence , linguistics , philosophy

Yersinia pestis , which causes bubonic plague, forms biofilms in fleas, its insect vectors, as a means to enhance transmission. Biofilm development is positively regulated byhmsT , encoding a diguanylate cyclase that synthesizes the bacterial second messenger cyclic-di-GMP. Biofilm development is negatively regulated by the Rcs phosphorelay signal transduction system. In this study, we show that Rcs-negative regulation is accomplished by repressing transcription ofhmsT.

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