Where To Begin? Mapping Transcription Start Sites Genome-Wide in Escherichia coli
Author(s) -
Joseph T. Wade
Publication year - 2014
Publication title -
journal of bacteriology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.652
H-Index - 246
eISSN - 1067-8832
pISSN - 0021-9193
DOI - 10.1128/jb.02410-14
Subject(s) - biology , escherichia coli , promoter , transcription (linguistics) , genome , gene , bacteriology , genetics , escherichia coli proteins , computational biology , bacterial genome size , transcription factor , gene expression , bacteria , linguistics , philosophy
Recent genome-wide studies of bacterial transcription have revealed large numbers of promoters located inside genes. In this issue of the Journal of Bacteriology, Thomason and colleagues (J. Bacteriol. 197:18-28, 2015, doi:10.1128/JB.02096-14) map transcription start sites in Escherichia coli on an unprecedented scale. This work provides important insights into the regulation of transcripts that initiate inside genes and sources of variability between studies aimed at identifying these RNAs.
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