TrpY Regulation of trpB2 Transcription in Methanothermobacter thermautotrophicus | Zendy

Elizabeth A. Karr | Zendy; Kathleen Sandman | Zendy; Rudi Lurz | Zendy; John N. Reeve | Zendy

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TrpY Regulation of trpB2 Transcription in Methanothermobacter thermautotrophicus

Author(s) -

Elizabeth A. Karr,

Kathleen Sandman,

Rudi Lurz,

John N. Reeve

Publication year - 2008

Publication title -

journal of bacteriology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.652

H-Index - 246

eISSN - 1067-8832

pISSN - 0021-9193

DOI - 10.1128/jb.01926-07

Subject(s) - biology , transcription (linguistics) , tryptophan , psychological repression , dna , microbiology and biotechnology , transcription factor , biochemistry , genetics , gene , amino acid , gene expression , philosophy , linguistics

TrpY binds specifically to TRP box sequences upstream of trpB2, but the repression of trpB2 transcription requires additional TrpY assembly that is stimulated by but not dependent on the presence of tryptophan. Inhibitory complex formation is prevented by insertions within the regulatory region and by a G149R substitution in TrpY, even though TrpY(G149R) retains both TRP box DNA- and tryptophan-binding abilities.

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