SarA ofStaphylococcus aureusBinds to thesarAPromoter To Regulate Gene Expression | Zendy

Ambrose L. Cheung | Zendy; Koren Nishina | Zendy; Adhar C. Manna | Zendy

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SarA ofStaphylococcus aureusBinds to thesarAPromoter To Regulate Gene Expression

Author(s) -

Ambrose L. Cheung,

Koren Nishina,

Adhar C. Manna

Publication year - 2008

Publication title -

journal of bacteriology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.652

H-Index - 246

eISSN - 1067-8832

pISSN - 0021-9193

DOI - 10.1128/jb.01826-07

Subject(s) - biology , staphylococcus aureus , gene , microbiology and biotechnology , gene expression , staphylococcus , expression (computer science) , staphylococcal infections , genetics , bacteria , computer science , programming language

The 375-bp sarA open reading frame is driven by three promoters, P1, P3, and P2. Using gel shift and DNase I footprinting assays, we found that SarA binds to two 26-bp sequences and one 31-bp sequence within the P1 and P3 promoters, respectively. Together with the results of transcription analyses, our data indicate that SarA binds to its own promoter to down-regulate sarA expression.

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