Differential Expression of sigH Paralogs during Growth and under Different Stress Conditions in Mycobacterium smegmatis | Zendy

Anirudh K. Singh | Zendy; B. N. Singh | Zendy

Open Access

Differential Expression of sigH Paralogs during Growth and under Different Stress Conditions in Mycobacterium smegmatis

Author(s) -

Anirudh K. Singh,

B. N. Singh

Publication year - 2009

Publication title -

journal of bacteriology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.652

H-Index - 246

eISSN - 1067-8832

pISSN - 0021-9193

DOI - 10.1128/jb.01773-08

Subject(s) - biology , mycobacterium smegmatis , antimycobacterial , transcription (linguistics) , gene , genetics , mycobacterium , genome , bacteria , mycobacterium tuberculosis , tuberculosis , medicine , linguistics , philosophy , pathology

SigH regulates a transcriptional network that responds to heat and oxidative stress in mycobacteria. Seven sigH paralogs are reported to exist in the Mycobacterium smegmatis genome. A comprehensive real-time reverse transcriptase PCR analysis during different stages of growth and upon exposure to various stress conditions and antimycobacterial compounds showed differential expression of sigH paralogs during stationary phase and severalfold increases in the levels of transcription of sigH1, sigH4, sigH5, sigH6, and sigH7 under specific stress conditions.

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