vfr , a Novel Locus Affecting Cysteine Protease Production in Streptococcus pyogenes | Zendy

Yongsheng Ma | Zendy; Amy E. Bryant | Zendy; Dan B. Salmi | Zendy; Eric R. McIndoo | Zendy; Dennis L. Stevens | Zendy

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vfr , a Novel Locus Affecting Cysteine Protease Production in Streptococcus pyogenes

Author(s) -

Yongsheng Ma,

Amy E. Bryant,

Dan B. Salmi,

Eric R. McIndoo,

Dennis L. Stevens

Publication year - 2009

Publication title -

journal of bacteriology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.652

H-Index - 246

eISSN - 1067-8832

pISSN - 0021-9193

DOI - 10.1128/jb.01771-08

Subject(s) - streptococcus pyogenes , biology , microbiology and biotechnology , pathogenesis , protease , cysteine protease , extracellular , locus (genetics) , streptococcus , gene , genetics , immunology , bacteria , staphylococcus aureus , enzyme , biochemistry

A gene unique to Streptococcus pyogenes, called vfr, that negatively regulates speB, an important extracellular proteinase, has been identified. Disruption of vfr markedly increased SpeB production in a clinical strain of S. pyogenes and relieved its growth phase dependency. These findings may provide important insights into the pathogenesis of invasive S. pyogenes infections.

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