Novel Monofunctional Histidinol-Phosphate Phosphatase of the DDDD Superfamily of Phosphohydrolases | Zendy

Hyun Sook Lee | Zendy; Yona Cho | Zendy; Jung-Hyun Lee | Zendy; Sung Gyun Kang | Zendy

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Novel Monofunctional Histidinol-Phosphate Phosphatase of the DDDD Superfamily of Phosphohydrolases

Author(s) -

Hyun Sook Lee,

Yona Cho,

Jung-Hyun Lee,

Sung Gyun Kang

Publication year - 2008

Publication title -

journal of bacteriology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.652

H-Index - 246

eISSN - 1067-8832

pISSN - 0021-9193

DOI - 10.1128/jb.01722-07

Subject(s) - biology , superfamily , phosphatase , phosphate , gene , biochemistry , thermococcus , alkaline phosphatase , genetics , enzyme , archaea

The TON_0887 gene was identified as the missing histidinol-phosphate phosphatase (HolPase) in the hyperthermophilic archaeon "Thermococcus onnurineus" NA1. The protein contained conserved motifs of the DDDD superfamily of phosphohydrolase, and the recombinantly expressed protein exhibited strong HolPase activity. In this study, we functionally assessed for the first time the monofunctional DDDD-type HolPase, which is organized in the gene cluster.

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