Open AccessRrp2, a σ 54 -Dependent Transcriptional Activator of Borrelia burgdorferi , Activates rpoS in an Enhancer-Independent Manner
Author(s) -
Jon S. Blevins,
Hai Jun Xu,
Ming He,
Michael V. Norgard,
Larry Reitzer,
Xiaoming Yang
Publication year - 2009
Publication title -
journal of bacteriology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.652
H-Index - 246
eISSN - 1067-8832
pISSN - 0021-9193
DOI - 10.1128/jb.01721-08
Subject(s) - rpos , biology , enhancer , borrelia burgdorferi , activator (genetics) , recombinant dna , transcription (linguistics) , microbiology and biotechnology , dna , borrelia , promoter , genetics , gene , gene expression , philosophy , antibody , linguistics
Rrp2 is the sole σ54 -dependent transcriptional activator present in theBorrelia burgdorferi genome. We showed that recombinant Rrp2 binds to DNA in a sequence-nonspecific manner. During infection, Rrp2 activates σ54 -dependentrpoS expression without an apparent upstream enhancer element commonly associated with other σ54 -dependent transcriptional activators.