ArylamineN-Acetyltransferase Responsible for Acetylation of 2-Aminophenols inStreptomyces griseus | Zendy

Hirokazu Suzuki | Zendy; Yasuo Ohnishi | Zendy; Sueharu Horinouchi | Zendy

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ArylamineN-Acetyltransferase Responsible for Acetylation of 2-Aminophenols inStreptomyces griseus

Author(s) -

Hirokazu Suzuki,

Yasuo Ohnishi,

Sueharu Horinouchi

Publication year - 2006

Publication title -

journal of bacteriology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.652

H-Index - 246

eISSN - 1067-8832

pISSN - 0021-9193

DOI - 10.1128/jb.01708-06

Subject(s) - streptomyces griseus , biology , acetylation , acetyltransferase , acetyltransferases , microbiology and biotechnology , streptomyces , bacterial protein , arylamine n acetyltransferase , biochemistry , genetics , bacteria , gene

An arylamine N-acetyltransferase (NAT) responsible for the N acetylation of exogenous 3-amino-4-hydroxybenzoic acid in Streptomyces griseus was identified and characterized. This enzyme was distinct from other eukaryotic and bacterial NATs in that it acetylated various 2-aminophenol derivatives more effectively than it acetylated 5-aminosalicylic acid, and thus it may be involved in the metabolism of xenobiotic compounds.

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