Relevance of DNA Alkylation Damage Repair Systems in Salmonella enterica Virulence | Zendy

Gerard Àlvarez | Zendy; Susana Campoy | Zendy; Denis A. Spricigo | Zendy; Laura Teixidó | Zendy; Pilar Cortés | Zendy; Jordi Barbé | Zendy

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Relevance of DNA Alkylation Damage Repair Systems in Salmonella enterica Virulence

Author(s) -

Gerard Àlvarez,

Susana Campoy,

Denis A. Spricigo,

Laura Teixidó,

Pilar Cortés,

Jordi Barbé

Publication year - 2010

Publication title -

journal of bacteriology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.652

H-Index - 246

eISSN - 1067-8832

pISSN - 0021-9193

DOI - 10.1128/jb.01693-09

Subject(s) - salmonella enterica , biology , virulence , salmonella , gene , microbiology and biotechnology , dna , bacteria , dna damage , dna repair , plasmid , enterobacteriaceae , genetics , escherichia coli

Systematic inactivation of pathways involved in DNA alkylation damage repair demonstrated that inactivation of theada ,ogt ,tag ,uvrA , andmfd genes is required to detect aSalmonella enterica virulence decrease. Furthermore, the fitness ofS. enterica , defective in these genes, is lowered only when the bacterium is orally, but not intraperitoneally, inoculated.

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