Open AccessThe Rcs Two-Component System Regulates Expression of Lysozyme Inhibitors and Is Induced by Exposure to Lysozyme
Author(s) -
Lien Callewaert,
Kristof Vanoirbeek,
Ine Lurquin,
Chris W. Michiels,
Abram Aertsen
Publication year - 2009
Publication title -
journal of bacteriology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.652
H-Index - 246
eISSN - 1067-8832
pISSN - 0021-9193
DOI - 10.1128/jb.01549-08
Subject(s) - lysozyme , regulon , biology , muramidase , complementation , peptidoglycan , escherichia coli , microbiology and biotechnology , enzyme , biochemistry , mutant , gene
TheEscherichia coli Rcs regulon is triggered by antibiotic-mediated peptidoglycan stress and encodes two lysozyme inhibitors, Ivy and MliC. We report activation of this pathway by lysozyme and increased lysozyme sensitivity when Rcs induction is genetically blocked. This lysozyme sensitivity could be alleviated by complementation with Ivy and MliC.