Open AccessEvidence of Localized Prophage-Host Recombination in the lytA Gene, Encoding the Major Pneumococcal Autolysin
Author(s) -
María Morales,
Pedro Garcı́a,
Adela G. de la Campa,
Josefina Liñares,
Carmen Ardanuy,
Ernesto Garcı́a
Publication year - 2010
Publication title -
journal of bacteriology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.652
H-Index - 246
eISSN - 1067-8832
pISSN - 0021-9193
DOI - 10.1128/jb.01501-09
Subject(s) - autolysin , biology , prophage , streptococcus pneumoniae , genetics , gene , recombination , allele , pneumolysin , microbiology and biotechnology , bacteria , escherichia coli , bacteriophage
According to a highly polymorphic region in the lytA gene, encoding the major autolysin of Streptococcus pneumoniae, two different families of alleles can be differentiated by PCR and restriction digestion. Here, we provide evidence that this polymorphic region arose from recombination events with homologous genes of pneumococcal temperate phages.