A Widely Conserved Gene Cluster Required for Lactate Utilization in Bacillus subtilis and Its Involvement in Biofilm Formation | Zendy

Yunrong Chai | Zendy; Roberto Kolter | Zendy; Richard Losick | Zendy

Open Access

A Widely Conserved Gene Cluster Required for Lactate Utilization in Bacillus subtilis and Its Involvement in Biofilm Formation

Author(s) -

Yunrong Chai,

Roberto Kolter,

Richard Losick

Publication year - 2009

Publication title -

journal of bacteriology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.652

H-Index - 246

eISSN - 1067-8832

pISSN - 0021-9193

DOI - 10.1128/jb.01464-08

Subject(s) - operon , bacillus subtilis , biology , repressor , biofilm , biochemistry , bacteria , gene , genome , genetics , microbiology and biotechnology , escherichia coli , gene expression

We report that catabolism ofl -lactate inBacillus subtilis depends on the previously uncharacterizedyvfV-yvfW-yvbY (herein renamedlutABC ) operon, which is inferred to encode three iron-sulfur-containing proteins. The operon is under the dual control of a GntR-type repressor (LutR, formerly YvfI) and the master regulator for biofilm formation SinR and is induced during growth in response tol -lactate. Operons with high similarity tolutABC are present in the genomes of a variety of gram-positive and gram-negative bacteria, raising the possibility that LutABC is a widely conserved and previously unrecognized pathway for the utilization ofl -lactate or related metabolites.

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