Open AccessNanoarchaeal Origin of Histone H3?
Author(s) -
Ulrike Friedrich-Jahn,
Joachim Aigner,
Gernot Längst,
John N. Reeve,
Harald Huber
Publication year - 2009
Publication title -
journal of bacteriology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.652
H-Index - 246
eISSN - 1067-8832
pISSN - 0021-9193
DOI - 10.1128/jb.01431-08
Subject(s) - biology , histone , dna , histone code , lineage (genetic) , genetics , histone h3 , nucleosome , histone h1 , microbiology and biotechnology , gene
NEQ288, one of two archaeal histones inNanoarchaeum equitans , has a unique four-residue insertion that closely resembles an insertion in the eukaryotic histone H3 lineage. NEQ288 bound DNA but did not compact DNA in vitro in the absence of NEQ348, the secondN. equitans archaeal histone. The properties of NEQ288 suggest an intermediate between the archaeal and H3 histone lineages and an evolutionary step toward the now-mandatory assembly of eukaryotic histones into heterodimers.