Streptococcus pyogenesCovRS Mediates Growth in Iron Starvation and in the Presence of the Human Cationic Antimicrobial Peptide LL-37 | Zendy

Barbara J. Froehlich | Zendy; Christopher S. Bates | Zendy; June R. Scott | Zendy

Open Access

Streptococcus pyogenesCovRS Mediates Growth in Iron Starvation and in the Presence of the Human Cationic Antimicrobial Peptide LL-37

Author(s) -

Barbara J. Froehlich,

Christopher S. Bates,

June R. Scott

Publication year - 2008

Publication title -

journal of bacteriology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.652

H-Index - 246

eISSN - 1067-8832

pISSN - 0021-9193

DOI - 10.1128/jb.01256-08

Subject(s) - operon , biology , streptococcus pyogenes , microbiology and biotechnology , antimicrobial , streptococcus , signal transduction , transcription (linguistics) , peptide , bacteria , effector , transcription factor , transporter , biochemistry , gene , genetics , staphylococcus aureus , escherichia coli , linguistics , philosophy

We found that the global regulatory two-component signal transduction system CovRS mediates the ability of group A streptococcus (GAS) to grow under two stresses encountered during infection: iron starvation and the presence of LL-37. We also showed that CovRS regulates transcription of the multimetal transporter operon that is important for GAS growth in a low concentration of iron.

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