Liberate and Grab It, Ingest and Digest It: the GbdR Regulon of the Pathogen Pseudomonas aeruginosa | Zendy

Erhard Bremer | Zendy

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Liberate and Grab It, Ingest and Digest It: the GbdR Regulon of the Pathogen Pseudomonas aeruginosa

Author(s) -

Erhard Bremer

Publication year - 2013

Publication title -

journal of bacteriology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.652

H-Index - 246

eISSN - 1067-8832

pISSN - 0021-9193

DOI - 10.1128/jb.01243-13

Subject(s) - regulon , betaine , pseudomonas aeruginosa , biology , microbiology and biotechnology , virulence , glycine , pathogen , carbenicillin , biochemistry , bacteria , mutant , amino acid , gene , genetics

The compatible solute glycine betaine is a powerful osmostress protectant, but many microorganisms can also use it as a nutrient. K. J. Hampel et al. (J. Bacteriol. 196:7-15, 2014) defined a regulon in the notorious pathogen Pseudomonas aeruginosa that comprises modules for the harvest and import of the glycine betaine biosynthetic precursor choline and its subsequent catabolism to pyruvate. The reported data link the GbdR activator with the metabolism of host-derived compounds (e.g., phosphocholine) and virulence traits of P. aeruginosa.

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