Group B Streptococcal Pilus Proteins Contribute to Adherence to and Invasion of Brain Microvascular Endothelial Cells | Zendy

Heather C. Maisey | Zendy; Mary E. Hensler | Zendy; Victor Nizet | Zendy; Kelly S. Doran | Zendy

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Group B Streptococcal Pilus Proteins Contribute to Adherence to and Invasion of Brain Microvascular Endothelial Cells

Author(s) -

Heather C. Maisey,

Mary E. Hensler,

Victor Nizet,

Kelly S. Doran

Publication year - 2007

Publication title -

journal of bacteriology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.652

H-Index - 246

eISSN - 1067-8832

pISSN - 0021-9193

DOI - 10.1128/jb.01153-06

Subject(s) - pilus , biology , microbiology and biotechnology , streptococcus , group a , blood–brain barrier , group b , streptococcaceae , central nervous system , streptococcus agalactiae , immunology , bacteria , virulence , genetics , neuroscience , gene , antibiotics , medicine

Surface filamentous structures known as pili have been discovered recently in the gram-positive streptococcal pathogens that cause invasive disease in humans, including group BStreptococcus (GBS). We show that two GBS proteins involved in pilus formation, encoded bypilA andpilB , also facilitate the interaction of this important agent of central nervous system infection with endothelial cells of the human blood-brain barrier.

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