LmrR Is a Transcriptional Repressor of Expression of the Multidrug ABC Transporter LmrCD in Lactococcus lactis | Zendy

Herfita Agustiandari | Zendy; Jacek Lubelski | Zendy; H. Bart van den Berg van Saparoea | Zendy; Oscar P. Kuipers | Zendy; Arnold J. M. Driessen | Zendy

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LmrR Is a Transcriptional Repressor of Expression of the Multidrug ABC Transporter LmrCD in Lactococcus lactis

Author(s) -

Herfita Agustiandari,

Jacek Lubelski,

H. Bart van den Berg van Saparoea,

Oscar P. Kuipers,

Arnold J. M. Driessen

Publication year - 2007

Publication title -

journal of bacteriology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.652

H-Index - 246

eISSN - 1067-8832

pISSN - 0021-9193

DOI - 10.1128/jb.01151-07

Subject(s) - biology , lactococcus lactis , repressor , atp binding cassette transporter , regulator , transcriptional regulation , tetr , gene , regulation of gene expression , genetics , transporter , gene expression , bacteria , lactic acid

LmrCD is an ABC-type multidrug transporter in Lactococcus lactis. LmrR encodes a putative transcriptional regulator. In a DeltalmrR strain, lmrCD is up-regulated. LmrR binds the promoter region of lmrCD and interacts with drugs that cause lmrCD up-regulation. This suggests that LmrR is a drug-dependent transcriptional regulator of lmrCD expression.

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