Response of Staphylococcus aureus to Salicylate Challenge | Zendy

James T. Riordan | Zendy; Arunachalam Muthaiyan | Zendy; Wayne Van Voorhies | Zendy; Christopher T. D. Price | Zendy; James E. Graham | Zendy; Brian J. Wilkinson | Zendy; John E. Gustafson | Zendy

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Response of Staphylococcus aureus to Salicylate Challenge

Author(s) -

James T. Riordan,

Arunachalam Muthaiyan,

Wayne Van Voorhies,

Christopher T. D. Price,

James E. Graham,

Brian J. Wilkinson,

John E. Gustafson

Publication year - 2006

Publication title -

journal of bacteriology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.652

H-Index - 246

eISSN - 1067-8832

pISSN - 0021-9193

DOI - 10.1128/jb.01149-06

Subject(s) - staphylococcus aureus , biology , efflux , antimicrobial , repressor , microbiology and biotechnology , gene , transcriptome , biochemistry , bacteria , gene expression , genetics

Growth of Staphylococcus aureus with the nonsteroidal anti-inflammatory salicylate reduces susceptibility of the organism to multiple antimicrobials. Transcriptome analysis revealed that growth of S. aureus with salicylate leads to the induction of genes involved with gluconate and formate metabolism and represses genes required for gluconeogenesis and glycolysis. In addition, salicylate induction upregulates two antibiotic target genes and downregulates a multidrug efflux pump gene repressor (mgrA) and sarR, which represses a gene (sarA) important for intrinsic antimicrobial resistance. We hypothesize that these salicylate-induced alterations jointly represent a unique mechanism that allows S. aureus to resist antimicrobial stress and toxicity.

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