Nitric Oxide and Oxygen Regulate Truncated Hemoglobin Gene Expression inFrankiaStrain CcI3 | Zendy

James Niemann | Zendy; Louis S. Tisa | Zendy

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Nitric Oxide and Oxygen Regulate Truncated Hemoglobin Gene Expression inFrankiaStrain CcI3

Author(s) -

James Niemann,

Louis S. Tisa

Publication year - 2008

Publication title -

journal of bacteriology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.652

H-Index - 246

eISSN - 1067-8832

pISSN - 0021-9193

DOI - 10.1128/jb.01100-08

Subject(s) - frankia , biology , nitric oxide , snap , gene expression , oxygen , hemoglobin , gene , strain (injury) , biochemistry , microbiology and biotechnology , symbiosis , genetics , bacteria , chemistry , root nodule , computer graphics (images) , organic chemistry , anatomy , computer science , endocrinology

The Frankia genome contains two truncated hemoglobin genes (hboN and hboO) whose functions remain to be determined. Nitric oxide (NO) generated by the addition of 400 microM SNAP (S-nitroso-N-acetylpenicillamine) caused a 10-fold increase in hboN gene expression but had no effect on hboO expression. The addition of the NO scavenger, carboxy-PT10, reduced the effect of SNAP. hboO gene expression increased under low-oxygen conditions, while hboN expression was unaffected. These results suggest that HboN may function in protection from nitrosative stress and that HboO may act as an oxygen transport molecule for increased respiration in hypoxic environments.

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