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Insights from the Genome Sequence of a Salmonella enterica Serovar Typhi Strain Associated with a Sporadic Case of Typhoid Fever in Malaysia
Author(s) -
KienPong Yap,
Cindy Shuan Ju Teh,
Ramani Baddam,
Lay Ching Chai,
Narender Kumar,
Suma Tiruvayipati,
Niyaz Ahmed,
Kwai Lin Thong
Publication year - 2012
Publication title -
journal of bacteriology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.652
H-Index - 246
eISSN - 1067-8832
pISSN - 0021-9193
DOI - 10.1128/jb.01062-12
Subject(s) - typhoid fever , biology , salmonella typhi , whole genome sequencing , salmonella enterica , serotype , comparative genomics , strain (injury) , salmonella , genome , virology , microbiology and biotechnology , pathogen , genomics , genetics , gene , bacteria , escherichia coli , anatomy
Salmonella enterica serovar Typhi is the causative agent of typhoid fever, which causes nearly 21.7 million illnesses and 217,000 deaths globally. Herein, we describe the whole-genome sequence of the Salmonella Typhi strain ST0208, isolated from a sporadic case of typhoid fever in Kuala Lumpur, Malaysia. The whole-genome sequence and comparative genomics allow an in-depth understanding of the genetic diversity, and its link to pathogenicity and evolutionary dynamics, of this highly clonal pathogen that is endemic to Malaysia.

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