pH-Dependent Activation of the BarA-UvrY Two-Component System inEscherichia coli | Zendy

Verónica Alejandra Mondragón | Zendy; Bernardo Franco | Zendy; Kristina Jonas | Zendy; Kazushi Suzuki | Zendy; Tony Romeo | Zendy; Öjar Melefors | Zendy; Dimitris Georgellis | Zendy

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pH-Dependent Activation of the BarA-UvrY Two-Component System inEscherichia coli

Author(s) -

Verónica Alejandra Mondragón,

Bernardo Franco,

Kristina Jonas,

Kazushi Suzuki,

Tony Romeo,

Öjar Melefors,

Dimitris Georgellis

Publication year - 2006

Publication title -

journal of bacteriology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.652

H-Index - 246

eISSN - 1067-8832

pISSN - 0021-9193

DOI - 10.1128/jb.01052-06

Subject(s) - escherichia coli , biology , response regulator , biofilm , motility , two component regulatory system , gene , microbiology and biotechnology , signal transduction , regulator , component (thermodynamics) , biochemistry , bacteria , genetics , bacterial protein , physics , thermodynamics , mutant

The barA and uvrY genes of Escherichia coli encode a two-component sensor kinase and a response regulator, respectively. Although this system plays a major role in the regulation of central carbon metabolism, motility, and biofilm formation by controlling the expression of the CsrB and CsrC noncoding RNAs, the environmental conditions and the physiological signal(s) to which it responds remain obscure. In this study, we explored the effect of external pH on the activity of BarA/UvrY. Our results indicate that a pH lower than 5.5 provides an environment that does not allow activation of the BarA/UvrY signaling pathway.

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