Open AccessUnraveling the Regulatory Network in Streptococcus pyogenes : the Global Response Regulator CovR Represses rivR Directly
Author(s) -
Samantha Roberts,
Gordon Churchward,
June R. Scott
Publication year - 2007
Publication title -
journal of bacteriology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.652
H-Index - 246
eISSN - 1067-8832
pISSN - 0021-9193
DOI - 10.1128/jb.01026-06
Subject(s) - biology , streptococcus pyogenes , regulator , response regulator , microbiology and biotechnology , streptococcus , genetics , bacterial protein , gene , bacteria , staphylococcus aureus
The response regulator CovR acts as a master regulator of virulence inStreptococcus pyogenes by repressing transcription of approximately 15% of the group A streptococcus genome directly or indirectly. We demonstrate that phosphorylated CovR represses transcription ofrivR directly by binding to conserved sequences located downstream from the promoter to block procession of RNA polymerase. This establishes the first link in a regulatory network where CovR interacts directly with other proteins that modulate gene expression.