Transcriptomic Analysis of the Sulfate Starvation Response ofPseudomonas aeruginosa | Zendy

Tewes Tralau | Zendy; Stéphane Vuilleumier | Zendy; Christelle Thibault-Carpentier | Zendy; Barry J. Campbell | Zendy; C. A. Hart | Zendy; Michael A. Kertesz | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Transcriptomic Analysis of the Sulfate Starvation Response ofPseudomonas aeruginosa

Author(s) -

Tewes Tralau,

Stéphane Vuilleumier,

Christelle Thibault-Carpentier,

Barry J. Campbell,

C. A. Hart,

Michael A. Kertesz

Publication year - 2007

Publication title -

journal of bacteriology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.652

H-Index - 246

eISSN - 1067-8832

pISSN - 0021-9193

DOI - 10.1128/jb.00889-07

Subject(s) - biology , pseudomonas aeruginosa , methionine , transcriptome , mucin , microbiology and biotechnology , gene , sulfur , cystic fibrosis , bacteria , biochemistry , gene expression , genetics , chemistry , amino acid , organic chemistry

Pseudomonas aeruginosa is an opportunistic pathogen that causes a number of infections in humans, but is best known for its association with cystic fibrosis. It is able to use a wide range of sulfur compounds as sources of sulfur for growth. Gene expression in response to changes in sulfur supply was studied inP. aeruginosa E601, a cystic fibrosis isolate that displays mucin sulfatase activity, and inP. aeruginosa PAO1. A large family of genes was found to be upregulated by sulfate limitation in both isolates, encoding sulfatases and sulfonatases, transport systems, oxidative stress proteins, and a sulfate-regulated TonB/ExbBD complex. These genes were localized in five distinct islands on the genome and encoded proteins with a significantly reduced content of cysteine and methionine. Growth ofP. aeruginosa E601 with mucin as the sulfur source led not only to a sulfate starvation response but also to induction of genes involved with type III secretion systems.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research