Role of Phosphopantetheinyl Transferase Genes in Antibiotic Production by Streptomyces coelicolor | Zendy

YaWen Lu | Zendy; Adrianna K. San Roman | Zendy; Amy M. Gehring | Zendy

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Role of Phosphopantetheinyl Transferase Genes in Antibiotic Production by Streptomyces coelicolor

Author(s) -

YaWen Lu,

Adrianna K. San Roman,

Amy M. Gehring

Publication year - 2008

Publication title -

journal of bacteriology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.652

H-Index - 246

eISSN - 1067-8832

pISSN - 0021-9193

DOI - 10.1128/jb.00865-08

Subject(s) - biology , streptomyces coelicolor , antibiotics , transferase , gene , streptomyces , streptomycetaceae , microbiology and biotechnology , genetics , actinomycetales , bacteria , biochemistry , enzyme

The phosphopantetheinyl transferase genes SCO5883 (redU) and SCO6673 were disrupted in Streptomyces coelicolor. The redU mutants did not synthesize undecylprodigiosin, while SCO6673 mutants failed to produce calcium-dependent antibiotic. Neither gene was essential for actinorhodin production or morphological development in S. coelicolor, although their mutation could influence these processes.

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