Open AccessThe Type III Pantothenate Kinase Encoded by coaX Is Essential for Growth of Bacillus anthracis
Author(s) -
Carleitta Paige,
Sean D. Reid,
Philip C. Hanna,
Al Claiborne
Publication year - 2008
Publication title -
journal of bacteriology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.652
H-Index - 246
eISSN - 1067-8832
pISSN - 0021-9193
DOI - 10.1128/jb.00860-08
Subject(s) - biology , bacillus anthracis , kinase , bacillus (shape) , microbiology and biotechnology , type (biology) , bacteria , genetics , ecology
InBacillus anthracis , the novel type III pantothenate kinase (PanKBa ; encoded bycoaX ) catalyzes the first committed step in coenzyme A biosynthesis. We have demonstrated by analyzing the growth characteristics of a conditionalcoaX mutant that PanKBa is an essential enzyme, thus contributing to its validation as a new antimicrobial target.