Metabolic Reprogramming of Vibrio cholerae Impaired in Respiratory NADH Oxidation Is Accompanied by Increased Copper Sensitivity | Zendy

Charlotte Toulouse | Zendy; Kristina Metesch | Zendy; Jens Pfannstiel | Zendy; Julia Steuber | Zendy

Open Access

Metabolic Reprogramming of Vibrio cholerae Impaired in Respiratory NADH Oxidation Is Accompanied by Increased Copper Sensitivity

Author(s) -

Charlotte Toulouse,

Kristina Metesch,

Jens Pfannstiel,

Julia Steuber

Publication year - 2018

Publication title -

journal of bacteriology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.652

H-Index - 246

eISSN - 1067-8832

pISSN - 0021-9193

DOI - 10.1128/jb.00761-17

Subject(s) - vibrio cholerae , biology , microbiology and biotechnology , respiratory system , copper , reprogramming , oxidation reduction , biochemistry , bacteria , chemistry , anatomy , genetics , organic chemistry , cell

The importance of the central metabolism for bacterial virulence has raised interest in studying catabolic enzymes not present in the host, such as NQR, as putative targets for antibiotics.Vibrio cholerae lacking the NQR, which is studied here, is a model to estimate the impact of specific NQR inhibitors on the phenotype of a pathogen. Our comparative proteomic study provides a framework to evaluate the chances of success of compounds directed against NQR with respect to their bacteriostatic or bactericidal action.

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