Open AccessA New ESX-1 Substrate in Mycobacterium marinum That Is Required for Hemolysis but Not Host Cell Lysis
Author(s) -
Rachel E. Bosserman,
Kathleen R. Nicholson,
Matthew M. Champion,
Patricia A. Champion
Publication year - 2019
Publication title -
journal of bacteriology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.652
H-Index - 246
eISSN - 1067-8832
pISSN - 0021-9193
DOI - 10.1128/jb.00760-18
Subject(s) - mycobacterium marinum , biology , virulence , microbiology and biotechnology , secretion , lytic cycle , mycobacterium tuberculosis , pathogen , intracellular parasite , mycobacterium , virology , bacteria , tuberculosis , genetics , intracellular , gene , biochemistry , medicine , pathology , virus
BothMycobacterium tuberculosis , the cause of human tuberculosis (TB), andMycobacterium marinum , a pathogen of ectotherms, use the ESX-1 secretion system to cause disease. There are many established similarities between the ESX-1 systems inM. tuberculosis and inM. marinum . Yet the two bacteria infect different hosts, hinting at species-specific functions of the ESX-1 system. Our findings demonstrate that MMAR_2894 is a PE protein secreted by the ESX-1 system ofM. marinum . We show that MMAR_2894 is required for the optimal secretion of mycobacterial proteins required for disease. Because theMMAR_2894 gene is not conserved inM. tuberculosis , our findings demonstrate that MMAR_2894 may contribute to a species-specific function of the ESX-1 system inM. marinum , providing new insight into how theM. marinum andM. tuberculosis systems differ.
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