Latency of the Lipid A Deacylase PagL Is Involved in Producing a Robust Permeation Barrier in the Outer Membrane of Salmonella enterica | Zendy

Kiyoshi Kawasaki | Zendy; Takayuki Manabe | Zendy

Open Access

Latency of the Lipid A Deacylase PagL Is Involved in Producing a Robust Permeation Barrier in the Outer Membrane of Salmonella enterica

Author(s) -

Kiyoshi Kawasaki,

Takayuki Manabe

Publication year - 2010

Publication title -

journal of bacteriology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.652

H-Index - 246

eISSN - 1067-8832

pISSN - 0021-9193

DOI - 10.1128/jb.00758-10

Subject(s) - salmonella enterica , biology , bacterial outer membrane , permeation , salmonella , bacteria , microbiology and biotechnology , latency (audio) , enzyme , membrane , biochemistry , biophysics , escherichia coli , gene , genetics , electrical engineering , engineering

Lipid A deacylase PagL, which detoxifies endotoxin, is latent in Salmonella enterica. This study determined the biological significance of this latency. PagL latency was beneficial for bacteria in producing a robust permeation barrier through lipid A modifications under host-mimetic conditions that induced the modification enzymes, including PagL.

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