Defining the Role of the Streptococcus agalactiae Sht-Family Proteins in Zinc Acquisition and Complement Evasion | Zendy

Pauline Moulin | Zendy; Vanessa Rong | Zendy; Adeline Ribeiro E Silva | Zendy; Victoria G. Pederick | Zendy; Émilie Camiade | Zendy; Laurent Méreghetti | Zendy; Christopher A. McDevitt | Zendy; Aurélia Hiron | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Defining the Role of the Streptococcus agalactiae Sht-Family Proteins in Zinc Acquisition and Complement Evasion

Author(s) -

Pauline Moulin,

Vanessa Rong,

Adeline Ribeiro E Silva,

Victoria G. Pederick,

Émilie Camiade,

Laurent Méreghetti,

Christopher A. McDevitt,

Aurélia Hiron

Publication year - 2019

Publication title -

journal of bacteriology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.652

H-Index - 246

eISSN - 1067-8832

pISSN - 0021-9193

DOI - 10.1128/jb.00757-18

Subject(s) - biology , streptococcus agalactiae , zinc , homeostasis , microbiology and biotechnology , streptococcus , genetics , bacteria , chemistry , organic chemistry

This study examined the role of the two streptococcal histidine triad (Sht) proteins ofStreptococcus agalactiae in zinc homeostasis and complement resistance. We showed that Sht and ShtII facilitate zinc homeostasis in conjunction with the metal-binding proteins Lmb and AdcAII. Here, we show that the Sht-family proteins are functionally redundant with overlapping roles in zinc uptake. Further, this work reveals that although the Sht-family proteins bind to factor Hin vitro this did not influence survival in human blood.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research