Open AccessA 5′ Leader Sequence Regulates Expression of Methanosarcinal CO Dehydrogenase/Acetyl Coenzyme A Synthase
Author(s) -
Kimberly L. Anderson,
Ethel E. Apolinario,
Sheridan R. MacAuley,
Kevin R. Sowers
Publication year - 2009
Publication title -
journal of bacteriology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.652
H-Index - 246
eISSN - 1067-8832
pISSN - 0021-9193
DOI - 10.1128/jb.00731-09
Subject(s) - biology , transcription (linguistics) , atp synthase , archaea , biochemistry , elongation , dehydrogenase , enzyme , microbiology and biotechnology , gene , philosophy , linguistics , materials science , ultimate tensile strength , metallurgy
In vivo expression of CO dehydrogenase/acetyl coenzyme A synthase inMethanosarcina spp. is coordinately regulated in response to substrate by at least two mechanisms: differential transcription initiation and early elongation termination near the 3′ end of a 371-bp leader sequence. This is the first report of regulation of transcription elongation in theArchaea .